Year: 2023
Type: article
Abstract: The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus. We observed reduced metalloproteases and increased inflammatory homeostatic protein transcription in the heart, with decreased serum pro-inflammatory cytokines (i.e., TNF-α, IL-15, IL-22, G-CSF, M-CSF, MCP-1), metabolic markers of inflammation (i.e., kynurenine/tryptophane ratio), and inflammatory prostaglandins, indicative of reduced systemic inflammation in animals infected under a KD. Taken together, these data suggest that a KD can alter the transcriptional and metabolic response in animals following SARS-CoV-2 infection with improved mice health, reduced inflammation, and restored amino acid, nucleotide, lipid, and energy currency metabolism.
Source: Communications Biology
Authors: Amelia Palermo, Shen Li, Johanna ten Hoeve, Akshay Chellappa, Alexandra Morris, Barbara Dillon, Feiyang Ma, Yijie Wang, Edward Cao, Byourak Shabane, Rebeca Acín-Perez, Anton Petcherski, A. Jake Lusis, Stanley Hazen, Orian S. Shirihai, Matteo Pellegrini, Vaithilingaraja Arumugaswami, Thomas G. Graeber, Arjun Deb
Language: English
Topic: Diet and metabolism studies
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Funders: U.S. Department of Health and Human Services, National Institutes of Health, Centers for Disease Control and Prevention, University of California, Los Angeles, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: Identifying therapeutic strategies for the multisystem genetic disorder Pseudoxanthoma Elasticum, Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicity, G2023250030, G3535678918, G4494193945, G5017364282, G6047482813, G7147529592, G7482855150, G756883103, Role of GPNMB in cardiac remodeling
OpenAlex ID: W4388287932