Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors
Year: 2022
Type: article
Abstract: The use of hematopoietic cell transplantation (HCT) has been increasing in older patients. However, the levels if distress, psychosocial functioning, and health-related quality of life (HRQOL) among older HCT survivors remains largely unknown. In this secondary analysis using data from 2 randomized controlled trials, we analyzed baseline Cancer and Treatment Distress (CTXD) and Confidence In Survivorship Information (CSI) surveys of HCT survivors who were age ≥60 years at the time of transplantation and alive and disease-free ≥1 year post-autologous or -allogeneic HCT. We analyzed associations of these parameters with the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the 12-Item Short Form Survey (SF-12) and a healthcare adherence (HCA) scale, after adjusting for transplantation and patient demographic factors. A total of 567 patients were included. The median patient age at HCT was 65 years, and 68% of the patients underwent autologous HCT. The median CTXD score was .7 (mild), and the greatest distress was reported in the "health burden" subscale. The median CSI score was 1.4 (moderate-high), with the lowest confidence reported in the "late effects" subscale. We found negative Spearman correlations between CTXD score and SF-12 PCS (P = -.59) and MCS (P = -.54) and positive Spearman correlations between CSI score and SF-12 PCS (P = .23) and MCS (P = .30). The median HCA scale score was high at .8. Male sex, autologous HCT, increased distress level, and worse CSI score were associated with lower use of preventive care. Older survivors experienced a low level of distress and moderate-high level of CSI at ≥1 year post-HCT. As lower distress and higher CSI were associated with improved HRQOL and optimized preventive HCA, CTXD/CSI measures can be used to individualize the care of older adult HCT survivors.
Authors: Sanghee Hong, Jing Zhao, Shu Wang, Han Wang, Ji-Hyun Lee, Nosha Farhadfar, Joseph P. McGuirk, Bipin N. Savani, Hashmi K. Shahrukh, Patrick Stiff, Nandita Khera, Theresa Hahn, Alison W. Loren, Samantha M. Jaglowski, William A. Wood, Wael Saber, Jan Cerny, Shernan G. Holtan, Jana M. Reynolds, Abhinav Deol, Heather Jim, Joseph Uberti, Victoria Whalen, Jean C. Yi, Jaime Preussler, K. Scott Baker, Bronwen E. Shaw, Steven Devine, Karen Syrjala, Navneet S. Majhail, John R. Wingard, Zeina Al-Mansour
Institutions: University Hospitals of Cleveland, Case Western Reserve University, University of Florida, University of Florida Health, The University of Kansas Health System, Vanderbilt University Medical Center, Mayo Clinic, Loyola University Medical Center, Loyola University Chicago, Roswell Park Comprehensive Cancer Center, University of Pennsylvania, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, University of North Carolina at Chapel Hill, Medical College of Wisconsin, University of Massachusetts Chan Medical School, University of Minnesota, Baylor University Medical Center, Wayne State University, The Barbara Ann Karmanos Cancer Institute, Moffitt Cancer Center, Fred Hutch Cancer Center, National Marrow Donor Program, Sarah Cannon
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W4309868422