Year: 2022
Type: article
Abstract: Hair loss affects millions of people at some time in their life, and safe and efficient treatments for hair loss are a significant unmet medical need. We report that topical delivery of quercetin (Que) stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in mice. We construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1α in endothelial cells. Skin administration of a HIF-1α agonist partially recapitulates the pro-angiogenesis and hair-growing effects of Que. Together, these findings provide a molecular understanding for the efficacy of Que in hair regrowth, which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine, and suggest a route of pharmacological intervention that may promote hair regrowth.
Source: Protein & Cell
Institutions: Capital Medical University, Xuan Wu Hospital of the Capital Medical University, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Stem Cell and Reproductive Biology, Shanghai Institute of Materia Medica, State Key Laboratory of Membrane Biology, Beijing Institute for Stem Cell and Regenerative Medicine, Salk Institute for Biological Studies, Beijing Institute of Genomics
Language: English
Topic: Hair Growth and Disorders
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
Awards: G1087497514, G1117754195, G1187093019, G1315155433, G1316309003, G1397717652, G1500470957, G1749427031, G1780715992, G1942136960, G1943491234, G2015743494, G202359054, G2045722200, G2053118874, G2075194163, G2149619913, G2317025226, G2480675241, G2679234170, G2874098611, G3088791492, G3150443997, G3221454377, G3311603076, G3383796173, G3421319557, G3713094572, G4130559742, G4264198362, G4329745212, G4365910665, G4424056804, G4481402905, G453067906, G4692003870, G4860364162, G4870708093, G5163844036, G5476282740, G5500080794, G5518203686, G5815346902, G5971860502, G5976668501, G6017193691, G6072460052, G6095286978, G6255687796, G6409886023, G6684708555, G6783417120, G6790151920, G6844520676, G6959441181, G71093025, G7125197902, G7160987604, G7411664847, G7554964200, G7681850430, G7747176477, G7819028244, G7863014348, G7869482849, G793329496, G7963275195, G8149791978, G8213732483, G824452537, G8265315788, G8322985783, G8363897453, G8376073748, G8626355075, G8846406857, G938453857, G964420151
OpenAlex ID: W4309909006