The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study
Year: 2022
Type: article
Study design: Observational Study
Abstract: Chronic inflammation is a continuous low-grade activation of the systemic immune response. Whereas downstream inflammatory markers are associated with atrial fibrillation (AF), upstream inflammatory effectors including eicosanoids are less studied. To examine the association between eicosanoids and incident AF. We used a liquid chromatography-mass spectrometry for the non-targeted measurement of 161 eicosanoids and eicosanoid-related metabolites in the Framingham Heart Study. The association of each eicosanoid and incident AF was assessed using Cox proportional hazards models and adjusted for AF risk factors, including age, sex, height, weight, systolic/diastolic blood pressure, current smoking, antihypertensive medication, diabetes, history of myocardial infarction and heart failure. False discovery rate (FDR) was used to adjust for multiple testing. Eicosanoids with FDR < 0.05 were considered significant. In total, 2676 AF-free individuals (mean age 66 ± 9 years, 56% females) were followed for mean 10.8 ± 3.4 years; 351 participants developed incident AF. Six eicosanoids were associated with incident AF after adjusting for multiple testing (FDR < 0.05). A joint score was built from the top eicosanoids weighted by their effect sizes, which was associated with incident AF (HR = 2.72, CI = 1.71–4.31,P = 2.1 × 10–5). In conclusion, six eicosanoids were associated with incident AF after adjusting for clinical risk factors for AF.
Source: Scientific Reports
Institutions: Boston University, Boston Medical Center, National Heart, Lung, and Blood Institute, Framingham Heart Study, Cleveland Clinic, Cleveland Clinic Research, University of California San Diego, Cedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute, University of Massachusetts Chan Medical School
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,190
Funders: American Heart Association, American College of Cardiology Foundation, European Commission, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, HORIZON EUROPE Marie Sklodowska-Curie Actions
Awards: Functional Genomics of Atrial Fibrillation, G1092208835, G1458407027, DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY, G1735617348, G2208403735, G2281899837, Assessing Alzheimer disease risk and heterogeneity using multimodal machine learning approaches, G2968107320, AFGen Consortium: Atrial Fibrillation Genomics to Functional Analyses, Mediators of Systemic Inflammation and Heart Failure Risk in the Community, Clinical and genetic prediction of lifetime risk of atrial fibrillation and its complications, Mapping the Plasma Exposome and its Association with Human Cardiovascular Disease, G3816301243, Multi-omic analysis of atrial metabolism, electrophysiology and AF progression, G434337789, Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study, Microbial contributions to the host metabolome, G5520316217, G5929062284, G6717867015, G7083494661, Vaccine Induced Immune-Inflammatory Response and Cardiovascular Risk, G8155099957, Prediction of AF incidence using PR interval measurements, echocardiographic data and biomarker profiles: Analyses within epidemiological Framingham Heart Study and LIFE Health Care Study cohorts, G8333208880, The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE), G8683204365, G9000135092, IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL, Cardiac microstructure and the immune-inflammatory response to SARS-CoV-2, CAPSITE: Community Assessment of Pain and Sensitization in the Elderly, American Heart Association Tobacco Center for Regulatory Science (A-TRAC) 2.0
OpenAlex ID: W4309918230