Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families
Year: 2022
Type: article
Study design: Observational Study
Abstract: Psychotic and affective disorders often aggregate in the relatives of probands with schizophrenia, and genetic studies show substantial genetic correlation among schizophrenia, bipolar disorder, and major depressive disorder. In this study, we examined the polygenic risk burden of bipolar disorder and major depressive disorder in 257 multiplex schizophrenia families (N = 1005) from the Irish Study of High-Density Multiplex Schizophrenia Families versus 2205 ancestry-matched controls. Our results indicate that members of multiplex schizophrenia families have an increased polygenic risk for bipolar disorder and major depressive disorder compared to population controls. However, this observation is largely attributable to the part of the genetic risk that bipolar disorder or major depressive disorder share with schizophrenia due to genetic correlation, rather than the affective portion of the genetic risk unique to them. These findings suggest that a complete interpretation of cross-disorder polygenic risks in multiplex families requires an assessment of the relative contribution of shared versus unique genetic factors to account for genetic correlations across psychiatric disorders.
Source: Schizophrenia
Institutions: Virginia Commonwealth University, RTI International
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,590
Awards: WTCCC2 core activities., G121526804, G1748488402, WTCCC2 core activities, Identification and functional analysis of susceptibility genes in multifactorial disease., Adapting machine learning methods to detect genetic loci specific to strictly defined MDD, G5402020829, Resource for psychoses genomics, Ireland (RPGI)., G6132732, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., WTCCC2 core activities., Whole Genome Sequencing in Irish Multiplex Schizophrenia Families, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., G8975541179, Understanding the genomic basis of problematic alcohol use through integrative analysis of multi-omics data
OpenAlex ID: W4309996859