Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation
Year: 2022
Type: article
Abstract: Natural Deep Eutectic Systems (NADES) composed of sugar and sugar alcohols have been studied and applied in a variety of biological applications. Understanding their interaction with water across dilution and temperature is inherently important for maximizing the utility of NADES. Herein a wide range of sugar:sugar-alcohol molar ratios were synthesized and characterized by viscosity, molar excess volume, differential scanning calorimetry, water activity, and confocal Raman cryomicroscopy. NADES were found to have greater viscosity, reduced heat of fusion, greater absolute molar excess volume, lower water activity, and stronger hydrogen bonding of water than non-NADES mixtures. This is hypothesized to be due to cumulatively stronger hydrogen bonding interactions between components in pure and diluted NADES with the strongest interactions in the water-rich region. This work provides useful data and further understanding of hydrogen bonding interaction strength for a wide range of molar ratios in pure to well-diluted forms.
Source: Journal of Molecular Liquids
Institution: University of Minnesota
Language: English
Subfield: Catalysis
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,560
Awards: NSF Engineering Research Center for Advanced Technologies for Preservation of Biological Systems (ATP-Bio), University of Minnesota Materials Research Science and Engineering Center, NNCI: Midwest Nano Infrastructure Corridor (MINIC), Multicomponent solutions for the preservation of cell therapy products
OpenAlex ID: W4310290796