Work

Validation of a post-radiolabeling bioconjugation strategy for radioactive rare earth complexes with minimal structural footprint

Year: 2022

Type: article

Abstract: The nine-coordinate aza-macrocycle DO3Apic-NO2 and its kinetically inert complexes [M(DO3A-pic-NO2)]− (M = La, Tb, Eu, Lu, Y) can be readily bioconjugated to surface accessible thioles on peptides and proteins with a minimal structural footprint.

Source: Chemical Communications

DOI: 10.1039/d2cc06128g

Authors: Raphael Lengacher, Alexia G. Cosby, Dariusz Śmiłowicz, Eszter Boros

Institution: Stony Brook University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Awards: G377677821, Cherenkov luminescence mediated excitation of discrete lanthanide optical probes, CAREER: Exploring Cherenkov Radiation for the In Situ Excitation of Discrete Luminescent Lanthanide Complexes