Cognition, function, and prevalent dementia in centenarians and near‐centenarians: An individual participant data (IPD) meta‐analysis of 18 studies
Year: 2022
Type: review
Abstract: INTRODUCTION: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. METHODS: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. RESULTS: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). DISCUSSION: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.12828
Authors: Yvonne Leung, Nir Barzilai, Agnieszka Batko‐Szwaczka, Nina Beker, Kathrin Boerner, Carol Brayne, Henry Brodaty, Karen Siu‐Lan Cheung, María M. Corrada, John D. Crawford, Alessia A. Galbussera, Yasuyuki Gondo, Henne Holstege, Marc Hulsman, Yoshiko Lily Ishioka, Daniela Jopp, Claudia H. Kawas, Jeff Kaye, Nicole A. Kochan, Bobo Hi‐Po Lau, Darren M. Lipnicki, Jessica W. Lo, Ugo Lucca, Steve R. Makkar, Gabriella Marcon, Peter Martin, Kenichi Meguro, Sofiya Milman, Leonard W. Poon, Angela Recchia, Oscar Ribeiro, Emma Riva, Christoph Rott, Sietske AM Sikkes, Ingmar Skoog, Blossom Stephan, Jan Szewieczek, Laetitia Teixeira, Mauro Tettamanti, Krzysztof Wilczyński, Perminder Sachdev
Institutions: UNSW Sydney, Centre for Healthy Brain Ageing, Albert Einstein College of Medicine, Medical University of Silesia, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Massachusetts Boston, University of Cambridge, University of Hong Kong, University of California, Irvine, Mario Negri Institute for Pharmacological Research, The University of Osaka, O. P. Jindal Global University, University of Lausanne, Oregon Health & Science University, Hong Kong Shue Yan University, University of Udine, University of Trieste, Iowa State University, Tohoku University, University of Georgia, Universidade do Porto, Centre for Health Technology and Services Research, University of Aveiro, Heidelberg University, University of Gothenburg, Newcastle University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: Social Determinants of Dementia, Healthy Aging and Well-being: Examining positive Health Assets and Resilience factors, Excess nutrients and the metabolic syndrome of aging, Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study, COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settings, POPULATION BASED MULTIDISCIPLINARY STUDY OF CENTENARIANS, Risk factors, early diagnosis, and effective interventions for neurocognitive disorders, Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging
OpenAlex ID: W4310565752