Work

Drosophila mojavensis – chico

Year: 2022

Type: article

Abstract: The insulin signaling pathway is a highly conserved pathway in animals and is central to nutrient uptake (Hietakangas and Cohen 2009; Grewal 2009). A key component of the pathway, encoding a substrate of the Insulin Receptor (InR) protein, chico binds to the InR and thus is also referred to as the Insulin Receptor Substrate (IRS). The IRS chico is essential to the control of cell and organ size (Goderdhan et al. 1999; Bohni et al. 1999), overall growth (Bakopoulos et al. 2020), including the sex-biased control of cell size and growth (Millington et al. 2021; Kim and O’Connor 2021), and is involved in lifespan (Clancy et al. 2001). We propose a gene model for the D. mojavensis ortholog of the D. melanogaster chico (chico) gene. The genomic region of the ortholog corresponds to the uncharacterized protein LOC6576893 (RefSeq accession XP_032585220.1) in the dmoj_caf1 Genome Assembly of D. mojavensis (GenBank Accession: GCA_000005175.1 - Chen et al., 2014; SRP006203). This model is based on RNA-Seq data from D. mojavensis (Chen et al., 2014; SRP006203) and chico in D. melanogaster using FlyBase release FB2022_04 (GCA_000001215.4; Larkin et al., 2021). D. mojavensis is part of the mulleri complex in the repleta species group within the subgenus Drosophila of the genus Drosophila (Wasserman 1992, Durando et al, 2000). It was first described by Patterson (Patterson and Crow, 1940). D. mojavensis specializes on rotting cactus as its host and is found in the Mojave and Sonoran Deserts of the southwestern United States and northwestern Mexico including the Baja Peninsula, as well as on the channel-islands off the coast of California (https://www.taxodros.uzh.ch). The Genomics Education Partnership maintains a mirror of the UCSC Genome Browser (Kent WJ et al., 2002; Gonzalez et al., 2021), which is available at https://gander.wustl.edu.

Source: PubMed Central

DOI: 10.17912/micropub.biology.000677