Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors
Year: 2022
Type: article
Abstract: (Cell Reports 40, 111289, August 30, 2022)In the original version of this article, the immunofluorescence image in the middle panel of Figure 1E, depicting Npas3+/−, was inadvertently duplicated from the rightmost panel, depicting Npas3−/−. This error occurred during the preparation of the figures and was only noticed after publication by a reader.Figure 1ENpas3-deficient mice show decreased astrocyte production in the developing cortex (original)Show full caption(E) PAX6 (green) and BrdU (red)-positive cells in WT, Npas3+/−, and Npas3−/− cortex at E16.5.View Large Image Figure ViewerDownload Hi-res image Download (PPT) (Cell Reports 40, 111289, August 30, 2022) In the original version of this article, the immunofluorescence image in the middle panel of Figure 1E, depicting Npas3+/−, was inadvertently duplicated from the rightmost panel, depicting Npas3−/−. This error occurred during the preparation of the figures and was only noticed after publication by a reader. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviorsLi et al.Cell ReportsAugust 30, 2022In BriefLi et al. find that NPAS3, a bHLH transcription factor, regulates astrocyte differentiation and astrocyte-neuron communication. Deficiency of NPAS3 results in abnormal astrogenesis and autistic-like behavior. This study reveals mechanistic insights regarding how the deficiency of a bHLH transcription factor in astrogenesis affects cortical development and complex behaviors. Full-Text PDF Open Access
Source: Cell Reports
Authors: Yuanyuan Li, Tianda Fan, Xianfeng Li, Liqiu Liu, Fengbiao Mao, Yi Li, Zhuang Miao, Cheng Zeng, Wei Song, Jinrong Pan, Shutang Zhou, Mary E. Sunday, Hongbing Wang, Yan Wang, Zhong Sheng Sun
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
OpenAlex ID: W4310860150