Community Survey Results Show that Standardisation of Preclinical Imaging Techniques Remains a Challenge
Year: 2022
Type: article
Study design: Observational Study
Abstract: PURPOSE: To support acquisition of accurate, reproducible and high-quality preclinical imaging data, various standardisation resources have been developed over the years. However, it is unclear the impact of those efforts in current preclinical imaging practices. To better understand the status quo in the field of preclinical imaging standardisation, the STANDARD group of the European Society of Molecular Imaging (ESMI) put together a community survey and a forum for discussion at the European Molecular Imaging Meeting (EMIM) 2022. This paper reports on the results from the STANDARD survey and the forum discussions that took place at EMIM2022. PROCEDURES: The survey was delivered to the community by the ESMI office and was promoted through the Society channels, email lists and webpages. The survey contained seven sections organised as generic questions and imaging modality-specific questions. The generic questions focused on issues regarding data acquisition, data processing, data storage, publishing and community awareness of international guidelines for animal research. Specific questions on practices in optical imaging, PET, CT, SPECT, MRI and ultrasound were further included. RESULTS: Data from the STANDARD survey showed that 47% of survey participants do not have or do not know if they have QC/QA guidelines at their institutes. Additionally, a large variability exists in the ways data are acquired, processed and reported regarding general aspects as well as modality-specific aspects. Moreover, there is limited awareness of the existence of international guidelines on preclinical (imaging) research practices. CONCLUSIONS: Standardisation of preclinical imaging techniques remains a challenge and hinders the transformative potential of preclinical imaging to augment biomedical research pipelines by serving as an easy vehicle for translation of research findings to the clinic. Data collected in this project show that there is a need to promote and disseminate already available tools to standardise preclinical imaging practices.
Source: Molecular Imaging and Biology
Institutions: University of Edinburgh, Erasmus MC, Ghent University, University of Cologne, University Hospital Cologne, Max Delbrück Center, Universitätsklinikum Aachen, RWTH Aachen University, University of Zurich, Medical University of Vienna, Amsterdam University Medical Centers, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,860
Awards: G107283358, Enabling advance imaging of synaptic function in living males and females over the course of the life-span with Positron Emission Tomography (PET), Strategic expansion of preclinical ultrasound imaging facility, G4400737086, SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle, Myocardial fibrosis and left ventricular remodelling in cardiovascular disease, Strategic expansion of preclinical ultrasound imaging facility, Enabling advance imaging of synaptic function in living males and females over the course of the life-span with Positron Emission Tomography (PET), G8965059024
OpenAlex ID: W4310939239