Work

Molecular Mechanism of Adenovirus Late Protein L4-100K Chaperones the Trimerization of Hexon

Year: 2022

Type: article

Abstract: Adenovirus vectors have been widely used in clinical trials of vaccines and gene therapy, although some deficiencies remain. Chimeric modification of the hexon was expected to improve the potency of preexisting immune evasion and targeting, but in many cases, viral packaging is prevented by the inability of the chimeric hexon to assemble correctly. So far, few studies have examined the mechanisms of hexon trimer assembly. Here, we show how the chaperone protein L4-100K contributes to the assembly of the adenovirus capsid protein hexon, and these data will provide a guide for novel adenovirus vector design and development, as we desired.

Source: Journal of Virology

DOI: 10.1128/jvi.01467-22