Year: 2022
Type: article
Abstract: Nanostructures that display controllable motions and functions are indispensable to build molecular nanomachines. Structural DNA nanotechnology, enabling precise design of complex static and dynamic structures, can be used to construct molecular nanomachines. However, designing complex dynamic structures that present multiple motion behaviors with different stimuli‐responsiveness is full of challenges. Herein, multistep transformations of DNA origami domino array (DODA) triggered by mechanical forces are developed. The DODA consists of small, modular DNA units, which can be regulated by the external forces. Under the expanding and contraction forces exerted by the DNA trigger and G‐quadruplex (G4)‐functionalized loop strand, the units are reconfigured, leading to the programmable transformations of DODA among three conformations. This multistep transformation strategy is applied to construct chiral plasmonic metamolecules, and analyze K+ via fluorescence resonance energy transfer (FRET) analysis. Moreover, the strategy shows a diversified approach to build the DNA‐based nanodevices, and may find potential applications in various fields.
Source: Small Structures
Authors: Yan Liu, Huan Ge, Yuqi Wang, Linlin Tang, Yufeng Pei, Sisi Fan, Yongxiu Song, Chuan Zhang, Jie Song
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,900
OpenAlex ID: W4310993784