Associations between diffusion MRI microstructure and cerebrospinal fluid markers of Alzheimer's disease pathology and neurodegeneration along the Alzheimer's disease continuum
Year: 2022
Type: article
Study design: Observational Study
Abstract: Introduction: White matter (WM) degeneration is a critical component of early Alzheimer's disease (AD) pathophysiology. Diffusion-weighted imaging (DWI) models, including diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), and mean apparent propagator MRI (MAP-MRI), have the potential to identify early neurodegenerative WM changes associated with AD. Methods: We imaged 213 (198 cognitively unimpaired) aging adults with DWI and used tract-based spatial statistics to compare 15 DWI metrics of WM microstructure to 9 cerebrospinal fluid (CSF) markers of AD pathology and neurodegeneration treated as continuous variables. Results: and pTau, compared with NODDI and DTI. Discussion: Our results suggest that WM degeneration may be more pervasive in AD than is commonly appreciated and that innovative DWI models such as MAP-MRI may provide clinically viable biomarkers of AD-related neurodegeneration in the earliest stages of AD progression.
DOI: 10.1002/dad2.12381
Institutions: University of Wisconsin–Madison, Sahlgrenska University Hospital, University of Gothenburg, UK Dementia Research Institute, UCL Queen Square Institute of Neurology, University College London, Roche (Switzerland), Roche Diagnostics International AG (Switzerland), William S. Middleton Memorial Veterans Hospital
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
Awards: G117713310, G1921883344, G1922473590, G2360966051, G2375471656, White matter degeneration: biomarkers in preclinical Alzheimer's Disease, Algebraic Formulations for Characterizing Structural Brain Connectivity Changes and Pathology Transmission Networks in Preclinical Alzheimer's Disease, G581591135, G631053645, G784528917, Wisconsin Registry for Alzheimer's Prevention, Wisconsin Alzheimer's Disease Research Center
OpenAlex ID: W4311021995