Year: 2022
Type: article
Study design: Observational Study
Abstract: Subfertility is a global problem affecting millions worldwide, with declining total fertility rates. Preconception dietary supplementation may improve fecundability, but the magnitude of impact remains unclear. This prospective cohort study aimed to examine the association of preconception micronutrient supplements with fecundability, measured by time to pregnancy (TTP). The study was conducted at KK Women's and Children's Hospital, Singapore, between February 2015 and October 2017, on 908 women aged 18-45 years old, who were trying to conceive and were enrolled in the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO). Baseline sociodemographic characteristics and supplement intake were collected through face-to-face interviews. The fecundability ratio (FR) was estimated using discrete-time proportional hazard modelling. Adjusting for potentially confounding variables, folic acid (FA) (FR 1.26, 95% confidence interval 1.03-1.56) and iodine (1.28, 1.00-1.65) supplement users had higher fecundability compared to non-users. Conversely, evening primrose oil supplement users had lower fecundability (0.56, 0.31-0.99) than non-users. In this study, preconception FA and iodine supplementation were associated with shortened TTP, while evening primrose oil use was associated with longer TTP. Nonetheless, the association between supplement use and the magnitude of fecundability changes will need to be further confirmed with well-designed randomised controlled trials.
Source: Nutrients
DOI: 10.3390/nu14235110
Authors: Chee Wai Ku, Chee Onn Ku, Liza Pui Chin Tay, Hui Kun Xing, Yin Bun Cheung, Keith M. Godfrey, Marjorelee T. Colega, Cherlyen Teo, Karen Mei Ling Tan, Yap-Seng Chong, Lynette Pei-Chi Shek, Kok Hian Tan, Shiao-Yng Chan, Shan Xuan Lim, Mary Foong-Fong Chong, Fabian Yap, Jerry Kok Yen Chan, See Ling Loy
Institutions: National University of Singapore, KK Women's and Children's Hospital, Duke-NUS Medical School, Tampere University, University of Tampere, National Health Service, University Hospital Southampton NHS Foundation Trust, MRC Lifecourse Epidemiology Unit, University of Southampton, Medical Research Council, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, National University Health System, Khoo Teck Puat Hospital, National University Hospital, Nanyang Technological University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,722
Funders: National Institute for Health and Care Research, British Heart Foundation, European Commission, National Research Foundation, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, National University Health System, National Institute for Health Research Southampton Biomedical Research Centre, Medical Research Council, National Medical Research Council, Erasmus+, Precursory Research for Embryonic Science and Technology
Awards: G103267656, G1044357915, G1321528303, G1394218233, G1418130382, G1503713314, G1659327504, Children of UPBEAT: a study of cardiovascular function in 10-year-old children of obese women who participated in an antenatal lifestyle intervention, G1727471521, G1777789460, G183778332, G1882858428, G1917706474, G1956390128, G195975639, G211523949, G2125390887, G213766589, G2154835441, G2188486458, G2312300077, G2400945375, G2596139817, G2680691856, G2693923786, G273463038, G2780654756, G2834708008, G2838213439, G2845401290, G3015108477, G3210728687, G3264401604, G3283226014, G3424013768, NIHR Senior Investigator Award, G3521509650, G3552626036, G3563071610, G3637715992, G365416998, G3778457340, G3873828540, G3883922659, G389277099, G4213458000, G427574963, G4331660922, G434559078, G4552378496, NIHR Senior Investigator Award, G4761043033, G4798765764, Capacity Building to Improve Early Nutrition and Health in South Africa, G486207801, G4871738219, G4964355645, G5023485246, G5045453097, G5068482306, G5090859494, G5114893925, G5125246644, G5196117068, G5224105001, G524590474, G5246421578, G5285226399, G5314364370, G5318721926, G5435949906, G5490188102, G566675739, G5755632036, G587834012, G606602278, G6153309438, G6206044308, G6261854341, G6408020244, G645171559, G6528848405, G6587044744, G6719865625, G6723020440, G6907919727, G71336211, G7212409199, G7295670324, G7348633402, G7388601084, G740803340, G7420601327, G7485733262, G7643966348, G7646392811, G7671148335, G7852524164, G7865205193, G7915200173, G8306461559, G8307928819, G8346907872, G8385395667, G8394143762, Nutrition, Development and Lifelong Health: Studies in European Populations, G8537882575, G854637805, G8606453147, G8651793750
OpenAlex ID: W4311053301