Year: 2022
Type: article
Abstract: In this issue of Blood, Ruggeri et al identify a novel mechanism by which donor NK cells in an allograft accelerate posttransplant immune reconstitution.1 In allogeneic bone marrow transplantation, a critical question has been how donor hematopoietic cells can eliminate cancer and restore normal blood counts with limited off-target graft-versus-host immune pathology.Twenty years ago, the Perugia team published a seminal report in Science that showed donor alloreactive NK cells reduce graft-versus-host disease (GVHD) in allogeneic transplants by ablating recipient antigen-presenting cells. 2 Now the team, led by Loredana Ruggeri and Andrea Velardi, has addressed the issue of how transplantation may lead to accelerated immune reconstitution.This question is of particular importance in the context of allo-transplant using grafts consisting of CD34 + donor hematopoietic progenitor cells depleted of donor T cells, B cells, and NK cells.
Source: Blood
Author: Edmund K. Waller
Institution: Emory University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4311067928