Biopsychosocial Response to the COVID-19 Lockdown in People with Major Depressive Disorder and Multiple Sclerosis
Year: 2022
Type: article
Abstract: BACKGROUND: Changes in lifestyle, finances and work status during COVID-19 lockdowns may have led to biopsychosocial changes in people with pre-existing vulnerabilities such as Major Depressive Disorders (MDDs) and Multiple Sclerosis (MS). METHODS: Data were collected as a part of the RADAR-CNS (Remote Assessment of Disease and Relapse-Central Nervous System) program. We analyzed the following data from long-term participants in a decentralized multinational study: symptoms of depression, heart rate (HR) during the day and night; social activity; sedentary state, steps and physical activity of varying intensity. Linear mixed-effects regression analyses with repeated measures were fitted to assess the changes among three time periods (pre, during and post-lockdown) across the groups, adjusting for depression severity before the pandemic and gender. RESULTS: Participants with MDDs (N = 255) and MS (N = 214) were included in the analyses. Overall, depressive symptoms remained stable across the three periods in both groups. A lower mean HR and HR variation were observed between pre and during lockdown during the day for MDDs and during the night for MS. HR variation during rest periods also decreased between pre- and post-lockdown in both clinical conditions. We observed a reduction in physical activity for MDDs and MS upon the introduction of lockdowns. The group with MDDs exhibited a net increase in social interaction via social network apps over the three periods. CONCLUSIONS: Behavioral responses to the lockdown measured by social activity, physical activity and HR may reflect changes in stress in people with MDDs and MS. Remote technology monitoring might promptly activate an early warning of physical and social alterations in these stressful situations. Future studies must explore how stress does or does not impact depression severity.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm11237163
Authors: S Siddi, I Giné-Vázquez, R Bailon, F Matcham, F Lamers, S Kontaxis, E Laporta, E Garcia, B Arranz, G Dalla Costa, A.I Guerrero Pérez, A. Zabalza, M Buron, G Comi, L. Leocani, P Annas, M Hotopf, BWJH Penninx, M Magyari, P. S. Sørensen, X Montalban, G Lavelle, A Ivan, C Oetzmann, M K White, S Difrancesco, P Locatelli, DC Mohr, J Aguiló, V Narayan, A Folarin, R Dobson, J Dineley, D Leightley, N Cummins, S Vairavan, Y Ranjan, Z Rashid, A Rintala, G De Girolamo, A Preti, S Simblett, T Wykes, PAB members, I Myin-Germeys, JM Haro
Institutions: Centro de Investigación Biomédica en Red de Salud Mental, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Universidad de Zaragoza, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro de Investigación Biomédica en Red, Instituto de Investigación en Ingeniería de Aragón, University of Sussex, King's College London, Amsterdam Public Health, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Universitat Autònoma de Barcelona, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, IRCCS San Raffaele Roma, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Centre d'Esclerosi Múltiple de Catalunya, Copenhagen University Hospital, Rigshospitalet, Danish Multiple Sclerosis Center, Casa di Cura Columbus, Lundbeck (Denmark), University of Bergamo, Northwestern University, Janssen Research & Development (United States), LAB University of Applied Sciences, KU Leuven, Centro San Giovanni di Dio Fatebenefratelli, University of Turin
Language: English
Topic: COVID-19 and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $2,513
Funders: NHS Blood and Transplant, South London and Maudsley NHS Foundation Trust, European Federation of Pharmaceutical Industries and Associations, NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Alzheimer's Society, National Institute for Health and Care Research, Department of Health and Social Care, King's College London, European Commission, ZonMw, King's Health Partners, Region Hovedstaden, Institut Català de la Salut, GIESKES-STRIJBIS FONDS, National Institutes of Health, NIHR BioResource, NIHR Maudsley Biomedical Research Centre, Medical Research Council, Menzies Centre for Australian Studies, King's College London, University of London, Health Data Research UK
OpenAlex ID: W4311162267