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The modifying influence of HLA class II DQB1∗06:02 on the Streptococcus and clinical phenotype correlation among anti-Ro+ mothers of children with neonatal lupus

Year: 2022

Type: article

Abstract: The modifying influence of HLA class II DQB1*06:02 on the Streptococcus and clinical phenotype correlation among anti-RoD mothers of children with neonatal lupusThe genus Streptococcus, a gram-positive bacterium, contains species associated with immune activation at morbid outcomes, including scarlet fever, endocarditis, meningitis, and rheumatic fever.In both stool and saliva, there is a positive correlation between Streptococcus abundance and Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE).1,2 Interestingly, the HLA class II DQB1*06:02 allele is both associated with the risk of SLE 3 and plays putative roles in Streptococcus biology such as mimicry of bacterial antigens and related host antigens, an event that is associated with a loss of tolerance.We hypothesized that the Strepto-coccuseSLE association might be mediated by the presence of SLE-risk allele DQB1*06:02.Similarly, intercellular adhesion molecule-1 (ICAM-1), also known as CD54, and B-cell activating factor (BAFF), also known as tumor necrosis factor ligand superfamily member 13B (TNFSF13B), are elevated in the serum of SLE patients.4 The serum protein levels of BAFF and ICAM1 may therefore further complicate the interplay among Streptococcus sp., DQB1*06:02, and SLE.Anti-Roþ mothers of children with neonatal lupus exhibit preclinical/early autoimmunity and are a population that may enable the identification of initiators of a first autoimmune response.The variation in Streptococcus relative abundance in anti-Roþ mothers of children with neonatal lupus noted above was present in both oral and gut mucosa and observed when contrasting healthy controls (HC) and two groups of anti-Roþ women spanning degrees of preclinical and clinical groups of SLE (i.e., women who were asymptomatic or had undifferentiated autoimmune syndrome (Asym/UAS), and women with SS or SLE).The current Peer review under responsibility of Chongqing Medical University.

Source: Genes & Diseases

DOI: 10.1016/j.gendis.2022.11.006