Consequences of collagen induced inflammatory arthritis on circadian regulation of the gut microbiome
Year: 2022
Type: article
Abstract: The gut microbiota is important for host health and immune system function. Moreover autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis, although the causes and consequences of this are not fully understood. It has become clear that the composition and metabolic outputs of the microbiome exhibit robust 24 h oscillations, a result of daily variation in timing of food intake as well as rhythmic circadian clock function in the gut. Here, we report that experimental inflammatory arthritis leads to a re-organization of circadian rhythmicity in both the gut and associated microbiome. Mice with collagen induced arthritis exhibited extensive changes in rhythmic gene expression in the colon, and reduced barrier integrity. Re-modeling of the host gut circadian transcriptome was accompanied by significant alteration of the microbiota, including widespread loss of rhythmicity in symbiont species of Lactobacillus, and alteration in circulating microbial derived factors, such as tryptophan metabolites, which are associated with maintenance of barrier function and immune cell populations within the gut. These findings highlight that altered circadian rhythmicity during inflammatory disease contributes to dysregulation of gut integrity and microbiome function.
Source: The FASEB Journal
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,200
Awards: G1218792915, G2764386394, Oral Barrier Immuno-Surviellance; alterations across the life-course, Amino acid availability acts as a critical environmental rheostat of mucosal ILC2 responses, Innate immune regulation of pathologic CD4+ T cell responses in inflammatory disease., G4310492565, Clock control of inflammation in the lung., G4855964044, Clock control of inflammation in the lung., G6312036920, The microbiome drives circadian rhythms in inflammation, G7535307234, How are daily rheumatoid arthritis symptoms linked to the body clock and the bacteria in the gut?, G797069378, G8309471567, G8920800619
OpenAlex ID: W4311539048