Work

2-Furanylmethyl N-(2-propenyl)carbamate

Year: 2022

Type: article

Abstract: The overexpression of protein phosphatase 5 (PP5) has been correlated to tumor cell reproduction, making it a candidate for small molecule drug therapy. Prior work has focused on functionalized and decorated scaffolds that maximize contacts within and around the active site. The assembly and testing of cantharidin derivatives decorated with functionalized attachments has been our focus in order to affect the optimal binding of PP5. Condensation of 2-hydroxymethylfuran with allyl isocyanate meets the metrics of the rapid installment of functionality, as part of the core scaffold. Once condensed, cycloaddition followed by hydrogenation produces the desired derivative of norcantharidin in three synthetic steps.

Source: Molbank

DOI: 10.3390/m1510

Authors: Noah C. Baker, Abby L. Mock, Ivy B. Nguyen, Savan D. Patel, David C. Forbes

Institution: University of South Alabama

Language: English

Topic: Beetle Biology and Toxicology Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $524