Year: 2022
Type: review
Abstract: Extracellular vesicles (EVs) are produced by various cells and exist in most biological fluids. They play an important role in cell-cell signaling, immune response, and tumor metastasis, and also have theranostic potential. They deliver many functional biomolecules, including DNA, microRNAs (miRNA), messenger RNA (mRNA), long non-coding RNA (lncRNA), lipids, and proteins, thus affecting different physiological processes in target cells. Decreased immunogenicity compared to liposomes or viral vectors and the ability to cross through physiological barriers such as the blood-brain barrier make them an attractive and innovative option as diagnostic biomarkers and therapeutic carriers. Here, we highlighted two types of cells that can produce functional EVs, namely, mesenchymal stem/stromal cells (MSCs) and regulatory T cells (Tregs), discussing MSC/Treg-derived EV-based therapies for some specific diseases including acute respiratory distress syndrome (ARDS), autoimmune diseases, and cancer.
Source: Journal of Molecular Medicine
Authors: Zahra Heydari, Maria Peshkova, Zeynep Burcin Gonen, Ianos Coretchi, Ahmet Eken, Arzu Hanım Yay, Muhammet Ensar Dogan, Nuriye Gokce, Hilal Akalin, Nastasia Kosheleva, Daniela Galea-Abdusa, Mariana Ulinici, Valentina Vorojbit, Anastasia Shpichka, Stanislav Groppa, Massoud Vosough, Mihail Todiras, Denis Butnaru, Yusuf Ozkul, Peter Timashev
Institutions: Sechenov University, Nicolae Testemițanu State University of Medicine and Pharmacy, Erciyes University, Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences, Lomonosov Moscow State University, Royan Institute, Academic Center for Education, Culture and Research
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G3593464302, G6444257319
OpenAlex ID: W4311718428