Work

Chlamydia trachomatis Enhances HIV Infection of Non-Activated PBMCs.

Year: 2022

Type: article

Abstract: , promoted HIV infection of freshly isolated CD4+ T cells. Together with our previous reports, we concluded that STIs such as CT and GC but not commensal bacteria like lactobacilli enhanced HIV infection, possibly through immune activation. Importantly, the enhancement effect of fixed CT on HIV infection may explain the failure of antibiotic treatments to reduce the HIV incidence. Combined strategies to inhibit STI growth and STI-mediated mucosal immune activation should be considered for HIV prevention in the settings of STIs.

Source: PubMed

Authors: Alina Veretennikova, Theresa L Chang

Institutions: Rutgers New Jersey Medical School, University of Medicine and Dentistry of New Jersey

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Awards: Role of IFNe in immune modulation and HIV infection, Defensins in STI-Mediated Enhanced HIV Infectivity