Work

Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases

Year: 2022

Type: article

Abstract: Neurodegenerative diseases (NDs) encompass a broad range of conditions characterized by progressive neuronal degeneration and death and manifesting with a variety of signs and symptoms ranging from reduced cognitive function to motor dysfunctions. NDs share a number of molecular and pathogenic mechanism, the most frequent of which is oxidative stress (OS). Currently, no ND is curative, and the therapies offered merely control symptoms or slow illness development. As a result, current therapy research has focused on developing multi-targeted therapeutic approaches. This approach is also consistent with natural product derivatives with multi-targeted characteristics, such as phytochemicals. Because of their antioxidant effects, alkaloids, one of the phytochemicals, have the potential to cure NDs by targeting the OS mechanism. Role of plant derived alkaloids (34) as antioxidant agents for NDs are summarized in this review.

Source: Health Sciences Review

DOI: 10.1016/j.hsr.2022.100071

Authors: Seda Sirin, Serap Nigdelioglu Dolanbay, Belma Aslim

Institution: Gazi University

Language: English

Topic: Medicinal Plants and Neuroprotection

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,900