Mid‐childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C‐reactive protein
Year: 2022
Type: article
Abstract: Background We previously reported an association of high fat mass levels from age 9 to 15 years with lower forced expiratory flow in 1 s (FEV 1 )/forced vital capacity (FVC) ratio (i.e., increased risk of airflow limitation) at 15 years. Here, we aimed to assess whether insulin resistance and C‐reactive protein (CRP) at 15 years partially mediate this association. Methods We included 2263 children from the UK Avon Longitudinal Study of Parents and Children population‐based cohort (ALSPAC). Four fat mass index (FMI) trajectories (“low,” “medium‐low,” “medium‐high,” “high”) from 9 to 15 years were previously identified using Group‐Based Trajectory Modeling. Data on CRP, glucose, insulin, and post‐bronchodilator FEV 1 /FVC were available at 15 years. We defined insulin resistance by the homeostasis model assessment‐estimated insulin resistance index (HOMA‐IR). We used adjusted linear regression models and a causal mediation analysis to assess the mediating role of HOMA‐IR and CRP. Results Compared to children in the “low” FMI trajectory, children in the “medium‐high” and “high” FMI trajectories had lower FEV 1 /FVC at 15 years. The percentage of the total effect explained by HOMA‐IR was 19.8% [−114.1 to 170.0] and 20.4% [1.6 to 69.0] for the “medium‐high” and “high” trajectories, respectively. In contrast, there was little evidence for a mediating role of CRP. Conclusion The association between mid‐childhood fat mass and FEV 1 /FVC ratio at 15 years may be partially mediated by insulin resistance.
Source: Pediatric Allergy and Immunology
DOI: 10.1111/pai.13894
Institutions: Universitat Pompeu Fabra, University of Zurich, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University of Bristol, MRC Integrative Epidemiology Unit, Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Municipal Institute for Medical Research, Hospital del Mar Research Institute, MRC Centre for Environment and Health, Imperial College London
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
Awards: G1502031688, G1684393010, G1793884970, ALSPAC: consolidation of a two generation cell line backed resource, for the study of the environment and genetic determinants of health and development from before birth to late puberty., G1924190148, G2179969359, Aging Lungs in European Cohorts, G3423777635, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being., G3915381216, G3987754321, G43203158, G434337789, G521056402, G540838531, G5605139710, G589846866, G6328075693, G6689231961, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being., G801210579, G8393905554, G8849190613
OpenAlex ID: W4312203551