Paying the brain's energy bill
Year: 2022
Type: review
Abstract: How have animals managed to maintain metabolically expensive brains given the volatile and fleeting availability of calories in the natural world? Here we review studies in support of three strategies that involve: 1) a reallocation of energy from peripheral tissues and functions to cover the costs of the brain, 2) an implementation of energy-efficient neural coding, enabling the brain to operate at reduced energy costs, and 3) efficient use of costly neural resources during food scarcity. Collectively, these studies reveal a heterogeneous set of energy-saving mechanisms that make energy-costly brains fit for survival.
Source: Current Opinion in Neurobiology
Authors: Zahid Padamsey, Nathalie L. Rochefort
Language: English
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,350
Funders: Wellcome Trust, Royal Society, Royal Commission for the Exhibition of 1851, European Commission, Simons Initiative for the Developing Brain, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council, H2020 European Research Council
Awards: Dynamic regulation of cortical information processing and energy expenditure by food availability, Neuronal circuits and synaptic mechanisms of experience-dependent plasticity., G434337789, How does the mammalian neocortex sense and adapt to metabolic state in health and disease?, Envisioning the Reward: Neuronal circuits for goal-directed learning, G7402901669
OpenAlex ID: W4312211297