Work

Renal Regeneration: Stem Cell-Based Therapies to Battle Kidney Disease

Year: 2019

Type: article

Abstract: While the worldwide prevalence of kidney disease is increasing rapidly, the current therapeutic repertoire for these patients is often limited to dialysis and organ transplantation. However, advances in developmental and stem cell biology have highlighted the potential of stem cells for the development of novel renal regeneration therapies. While there are currently no approved stem cell-based treatments for kidney disease, various types of stem cells have been shown to facilitate regeneration of kidney tissue in preclinical models of both acute and chronic kidney injury. This review summarises the current status of stem cell-based therapies to battle kidney disease. In addition, future directions for the clinical translation of stem cell research towards development of novel renal regeneration therapies are discussed.

Source: EMJ Nephrology

DOI: 10.33590/emjnephrol/10311868

Authors: Takuya Matsumoto, Olivier J.M. Schäffers, Wenqing Yin, Ryuji Morizane

Institutions: Brigham and Women's Hospital, Harvard University, Wyss Institute for Biologically Inspired Engineering, Harvard Stem Cell Institute

Language: English

Topic: Renal and related cancers

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4312771607

FWCI: 0.166

Cites: 81

Cited by: 2

Related to: 10