Exploring FLOT- and FOLFOX-Based total neoadjuvant therapy for patients with locally advanced gastroesophageal cancers
Year: 2022
Type: article
Abstract: Understanding the currently available evidence regarding multimodal approaches is critically important. The Southwest Oncology Group INT-0116 trial demonstrated improved overall survival and disease-free survival using adjuvant therapy-specifically CRT-compared to surgery alone Subsequently, several other studies have supported the use of postoperative chemotherapy and/or CRT in addition to surgery with improved outcomes This was followed by the MAGIC trial, which demonstrated a survival advantage for the use of perioperative combination chemotherapy (epirubicin, cisplatin,) as compared to resection alone and
Source: Cancer Reports and Reviews
DOI: 10.15761/crr.1000238
Authors: Eric J Roeland, Katie Kanter, Samuel J Klempner, Ryan D Nipp, Avinash Kambadakone, Aparna Parikh, Brenna Casey, Kumar Krishnan, David P Ryan, Jill N Allen, Ryan B Corcoran, Bruce Giantonio, Colin Weekes, Lipika Goyal, John Dubois, Lauren Dias, Lawrence Blaszkowsky, Florence K Keane, Hugh G Auchincloss, Henning Gaissert, Christopher R Morse, Michael Lanuti, David Berger, Jennifer Y Wo, Theodore S Hong, John T Mullen, Jeffrey W. Clark
Institutions: Massachusetts General Hospital, Harvard University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4312920087