Progress in Transition Metal-Catalyzed Asymmetric Ring-Opening Reactions of Epoxides and Aziridines
Year: 2022
Type: article
Abstract: Epoxides and aziridines are important three-membered cyclic compounds, which exhibit high reactivity due to their strong strain in molecules.The asymmetric ring-opening reactions of epoxides and aziridines catalyzed by transition metals are efficient strategies for the construction of chiral molecules containing O/N atoms.In this way, a series of chiral alcohols, chiral amines and chiral heterocycles can be constructed.The recent progress in transition metal-catalyzed asymmetric ring-opening reactions of epoxides and aziridines in the past two decades is reviewed with emphasis on the influence of the kinds of transition metal catalysts, nucleophiles, and ligands.Furthermore, the possible reaction mechanisms and applications for the asymmetric ring-opening reactions are discussed, and the future development in this field is also prospected.Keywords transition metals catalysis; epoxide; aziridine; asymmetric ring-opening reaction; nucleophilic coupling 含氧、氮杂原子的手性分子是药物、天然产物、生 物活性分子和手性催化剂中的重要组成部分, 在合成化 学、药物化学和生物医药等领域中有着广泛的应用 [1] .2021 年全球销售额 Top100 的药物中, 含有氧、氮杂原 子的手性药物占比高达 25% [2] .发展高效合成含氧、氮 杂原子手性分子的方法具有巨大的经济价值和实际意 义, 这也是众多科研工作者长期关注的研究方向. 氧/氮 杂环丙烷是一类非常重要的三元杂环分子, 且易于制 备 [3] .同时, 由于氧/氮杂环丙烷分子的环张力及易受催 化剂调控等特性, 它们能够选择性地发生各类开环反 应 [4]
Authors: Qingfeng Du, Lu Zhang, Feng Gao, Le Wang, Wanbin Zhang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G4551000957, G7786264078
OpenAlex ID: W4312928812