Work

Editor's evaluation: Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

Year: 2022

Type: peer-review

Abstract: Organellar lipidomics and lipid reporter studies in intact cells reveal how disease-relevant mutations in a sphingolipid biosynthetic enzyme cause a wide-ranging perturbation of lipid distributions and membrane properties along the secretory pathway.

DOI: 10.7554/elife.79278.sa0

Author: Arun Radhakrishnan

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4313142242

Cites:

Cited by:

Related to: 10