Work

Immune microenvironment dysfunctions enable malignification at the onset of myelodysplastic syndromes

Year: 2022

Type: conference-paper

Abstract: Myelodysplastic syndromes (MDS): clonal stem cell malignancies • Standard therapy not curative, transient responses, poor prognosis • Are prevention or early intervention possible in MDS? • Clonal cytopenias of undetermined significance (CCUS): aging-related premalignant state, low-grade clonal hematologic disorders at high risk of progression to MDS and leukemia • HSC-intrinsic alterations and extrinsic inflammatory factors cooperate to induce abnormal differentiation in CCUS (Ganan-Gomez et al.ASH Meeting 2021).

Source: Leading Edge of Cancer Research Symposium

DOI: 10.52519/00055

Authors: Irene Ganan-Gomez, Feiyang Ma, Kelly S. Chien, Hui Yang, Guillermo Montalvan-Bravo, Bethany E. Wildeman, Bijender Kumar, Yi June Kim, May Daher, Koichi Takahashi, Guillermo Garcia-Manero, Simona Colla

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4313159664

FWCI:

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