Year: 2022
Type: review
Abstract: In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector. Although several cellular, molecular, and genetic mechanisms have been proposed to explain the drug resistance mechanism in fungi, but a complete understanding of the molecular and genetic mechanisms is still lacking. Besides the genetic mechanism, epigenetic mechanisms are pivotal in the fungal lifecycle and disease biology. However, very little is understood about the role of epigenetic mechanisms in the emergence of multi-drug resistance in fungi, especially in Candida auris (C. auris). The current narrative review summaries the clinical characteristics, genomic organization, and molecular/genetic/epigenetic mechanisms underlying the emergence of drug resistance in C. auris. A very few studies have attempted to evaluate the role of epigenetic mechanisms in C. auris. Furthermore, advanced genetic tools such as the CRISP-Cas9 system can be utilized to elucidate the epigenetic mechanisms and their role in the emergence of multi-drug resistance in C. auris.
Authors: Ali A. Rabaan, Khalid Eljaaly, Wadha A. Alfouzan, Abbas Al Mutair, Saad Alhumaid, Amal H. Alfaraj, Yahya Aldawood, Abdulmonem A. Alsaleh, Hawra Albayat, Reyouf Al Azmi, Nawal AlKaabi, Samira J. Alzahrani, Salma AlBahrani, Tarek Sulaiman, Abeer N. Alshukairi, Abdulmonem A. Abuzaid, Mohammed Garout, Rafiq Ahmad, Javed Muhammad
Institutions: Alfaisal University, Saudi Aramco Medical Services Organization, University of Haripur, University of Arizona, King Abdulaziz University, Farwaniya Hospital, Kuwait University, Princess Nourah bint Abdulrahman University, University of Wollongong, Prince Sultan Military College of Health Sciences, Ministry of Health, Mohammed Almana College for Medical Sciences, King Saud Medical City, Khalifa University of Science and Technology, Shaikh Khalifa Medical City, Abu Dhabi Health Services, King Fahd Military Medical Complex, King Fahd Medical City, King Faisal Specialist Hospital & Research Centre, Security Forces Hospital, Umm al-Qura University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4313252825