Work

Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions

Year: 2022

Type: review

Abstract: Radiotherapy is applied in about 70% patients with tumors, yet radioresistance of tumor cells remains a challenge that limits the efficacy of radiotherapy. Ferroptosis, an iron-dependent lipid peroxidation regulated cell death, is involved in the development of a variety of tumors. Interestingly, there is evidence that ferroptosis inducers in tumor treatment can significantly improve radiotherapy sensitivity. In addition, related studies show that Glutathione S-transferase P1 (GSTP1) is closely related to the development of ferroptosis. The potential mechanism of targeting GSTP1 to inhibit tumor cells from evading ferroptosis leading to radioresistance has been proposed in this review, which implies that GSTP1 may play a key role in radiosensitization of lung cancer via ferroptosis pathway.

Source: Frontiers in Molecular Biosciences

DOI: 10.3389/fmolb.2022.1102158

Authors: Xin Tan, Xiang Huang, Baolong Niu, Xingdong Guo, Xiao Lei, Baolin Qu

Institutions: Chinese PLA General Hospital, First Affiliated Hospital of Chinese PLA General Hospital

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950