Year: 2022
Type: review
Abstract: This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.
Source: Physics in Medicine and Biology
Authors: Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan van Hoof, Ioannis L Verginadis, Jan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois
Institutions: Maastricht University Medical Centre, Maastro Clinic, Queen's University Belfast, University of Glasgow, University Medical Center Groningen, University of Groningen, TUM Klinikum, Helmholtz Munich, Technical University of Munich, University College London, Erasmus MC, Demcon (Netherlands), University of Oxford, CRUK/MRC Oxford Institute for Radiation Oncology, University of Pennsylvania, LMU Klinikum, Deutsches Konsortium für Translationale Krebsforschung, Ludwig-Maximilians-Universität München, University of Rochester Medicine, University of Rochester, National Physical Laboratory, University of Manchester, Henry Ford Health, Beaumont Health, Henry Ford Hospital, Maastricht University
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,930
Funders: University of Pennsylvania, Abramson Cancer Center, Cancer Research UK, European Commission, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Perelman School of Medicine, University of Pennsylvania, Medical Research Council, Elitenetzwerk Bayern, H2020 European Research Council, Eurostars
Awards: G2526064325, G3280748682, G3979912349, G4291948961, G430075018, G434337789, G4626242555, G4869084219, G5522554483, International NETwork for training and innovations in THErapeutic RADiation, Spatio-temporal dependency of radiotherapy induced cardiac toxicity in a novel preclinical model, G6590773636, G6747769491, SFB 1321: Modellierung und Targeting des Pankreaskarzinoms, Small animal proton Irradiator for Research in Molecular Image-guided radiation-Oncology, G876849910
OpenAlex ID: W4313339686