Work

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Year: 2022

Type: review

Abstract: Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

Source: Toxics

DOI: 10.3390/toxics11010032

Authors: Xing Zhang, Jodi A. Flaws, Michael J. Spinella, Joseph Irudayaraj

Institutions: University of Illinois Urbana-Champaign, Carl R. Woese Institute for Genomic Biology, Cancer Center at Illinois

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,885