Year: 2023
Type: article
Abstract: In recent years, in a number of countries, when screening for various diseases of the stomach, including peptic ulcer of the stomach and duodenum, gastroesophageal reflux, atrophic gastritis and other diseases of the stomach, the invasive endoscopy method has been replaced by more effective and easier non-invasive methods. Therefore, a number of studies have been carried out [2, 3, 4]. As a result of these studies, it was found that the change in the amount of pepsinogen I (PGI), pepsinogen II (PGII) in the blood serum can be used as a biological marker of these diseases, and their concentration in the blood serum determines the morphofunctional state of the stomach wall, and in the future, when detected changes, the diagnosis is confirmed by histological examination [1]. Pepsinogens are inactive pepsin precursor proteins that are converted to catalytically active pepsin in the presence of hydrochloric acid in the stomach. In healthy people, PGI is normally produced three times higher than PGII. It is known that the gastric mucosa, regardless of the mechanism of its damage, is able to regenerate and restore its original structure. At the same time, with progressive inflammation of the gastric mucosa, damaged glands lose their ability to regenerate, and metaplastic epithelial cells appear instead of the mucous membrane, which leads to atrophic gastritis [5].
Institution: Samarkand State Medical Institute
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4313377266