TDP-43 Pathology in the Setting of Intermediate and High Alzheimer’s Disease Neuropathologic Changes: A Preliminary Evaluation Across Ethnoracial Groups
Year: 2023
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Transactive Response DNA Binding Protein 43 kDa (TDP-43) pathology is frequently found in cases with Alzheimer's disease (AD). TDP-43 pathology is associated with hippocampal atrophy and greater AD severity denoted by cognition and clinical representation. Current TDP-43 pathology studies are predominantly based on non-Hispanic White cohorts. OBJECTIVE: We sought to evaluate the presence of TDP-43 pathology across ethnoracial groups utilizing the National Alzheimer's Coordinating Center; a database containing data from over 29 institutions across the United States. Cases (N = 1135: Hispanics/Latinos = 29, African Americans/Black Americans = 51, Asians/Asian Americans = 10, American Indians/Alaskan Natives = 2, non-Hispanic White = 1043) with intermediate/high AD having data on TDP-43 pathology in the amygdala, hippocampus, entorhinal cortex, and neocortex were included. METHODS: TDP-43 pathology frequency in each neuroanatomic region among ethnoracial groups were compared using generalized linear mixed effects models with center as a random effect adjusting for age at death, education, and gender. RESULTS: Although groups were imbalanced, there was no significant difference across ethnoracial groups based on TDP-43 pathology (p = 0.84). With respect to neuroanatomical regions evaluated, there were no significant differences across ethnoracial groups (p-values > 0.06). There were also no significant differences for age at death and gender ratios across ethnoracial groups based on TDP-43 pathology. Although not statistically significant, TDP-43 pathology was present less often in Hispanic/Latinos (34%) when compared to non-Hispanic Whites (46%). CONCLUSION: While this is a preliminary evaluation, it highlights the need for diverse cohorts and on TDP-43 pathology research across ethnoracial groups. This is the first study to our knowledge having a focus on the neuroanatomical distribution of TDP-43 deposits in Hispanic/Latino decedents with AD.
Source: Journal of Alzheimer s Disease
DOI: 10.3233/jad-220558
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1017046091, G1053905225, G1069732457, G1104192986, G113062254, G1171648585, G1228824270, G1282666458, Michigan Alzheimer's Disease Core Center, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, G1375833519, G1417337112, G1492531059, G1593128567, G1602633198, G1663213784, G1778344677, G2075747288, G2190936067, G219693323, G234895681, G2515091901, Neurobiology of Alzheimer's Disease and Aging, G2640555407, G2675915175, G270366201, G2769554943, G2984989008, G3036763132, G3066742295, G3335858628, G3359100610, G3439557519, G384347443, G3919444319, G3946457848, G40706755, G4076092645, G4103239427, G413369726, G4186766937, G423967958, G4318823550, G4417220376, G4684857399, G496605150, G511679733, G556672640, G5870618905, G5977822913, G603598372, G611802359, G6492025387, University of Kansas Alzheimer's Disease Core Centers, G6750444795, Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, G7409097460, Boston University Alzheimer's Disease Center, Alzheimer's Disease Core Center, G7911027991, G8018240826, University of Florida - Mt. Sinai Medical Center AD Research Center, G816726602, G828200374, G873702183, G9000000531, G9000003466, G9000004804, G9000005508, G9000008846, G9000013408, G9000017672, G9000018678, G9000020322, G9000021351, G9000024008, G9000025891, G9000030722, G9000031515, G9000032698, G9000033698, G9000035486, G9000036492, G9000038514, G9000044543, G9000046703, G9000064269, G9000070217, G9000074900, G9000082286, G9000092781, G9000099765, G9000104082, G9000108235, G9000119544, G9000126115, G9000131182, G9000132673, G9000145746, G9000147311, G9000151373, G9000167101, G9000167254, G9000208643, G9000208846, G9000212151, G9000218452, G9000218858, G9000227227, G9000227779, G9000247065, G9000252716, G9000254440, G9000274623, G9000307348, G9000352745, G9000354213, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Culturally relevant contributors to cognitive and MRI changes in older Latinos, Alzheimer's Disease Research Centers
OpenAlex ID: W4313458577