Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder
Year: 2023
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Cholinergic nucleus 4 (Ch4) degeneration is associated with cognitive impairment in Parkinson's disease and dementia with Lewy bodies, but it is unknown if Ch4 degeneration is also present in isolated rapid eye movement sleep behavior disorder (iRBD). OBJECTIVE: The aim was to determine if there is evidence of Ch4 degeneration in patients with iRBD and if it is associated with cognitive impairment. METHODS: We analyzed the clinical and neuropsychological data of 35 iRBD patients and 35 age- and sex-matched healthy controls. Regional gray matter density (GMD) was calculated for Ch4 using probabilistic maps applied to brain magnetic resonance imaging (MRI). RESULTS: Ch4 GMD was significantly lower in the iRBD group compared to controls (0.417 vs. 0.441, P = 0.02). Ch4 GMD was also found to be a significant predictor of letter number sequencing (β-coefficient = 58.31, P = 0.026, 95% confidence interval [7.47, 109.15]), a measure of working memory. CONCLUSIONS: iRBD is associated with Ch4 degeneration, and Ch4 degeneration in iRBD is associated with impairment in working memory. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Source: Movement Disorders
DOI: 10.1002/mds.29306
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,070
Funders: Michael J. Fox Foundation for Parkinson's Research, Eli Lilly and Company, McKnight Foundation, Biogen, CHDI Foundation, University of Rochester, International Parkinson and Movement Disorder Society, Jazz Pharmaceuticals, Parkinson's Foundation, National Institutes of Health, Administration for Community Living, Center for Clinical and Translational Research, School of Medicine, Virginia Commonwealth University, National Institute on Aging, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Dystonia Coalition
Awards: Dystonia Coalition, The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients, Factors Associated with Healthcare Utilization Among Community-Dwelling Adults with Clinical Features of Dementia with Lewy Bodies, G3885130535, SCH: Context-aware Freezing of Gait mitigation in real-world setting, Development and characterization of EEG signature of cognitive fluctuations in Lewy body dementia, G9000076568, Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis, Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease, ENIGMA Parkinson’s Initiative: A Global Initiative for Parkinson’s Disease
OpenAlex ID: W4313488606