Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson’s disease versus essential tremor
Year: 2022
Type: article
Study design: Observational Study
Abstract: Introduction Mood symptoms are common features of Parkinson’s disease (PD) and essential tremor (ET) and have been linked to worse cognition. The goals of the present study were to compare the severity of anxiety, apathy, and depressive symptoms in PD, ET, and healthy controls (HC) and to examine differential relationships between mood and cognition.Method Older adults with idiopathic PD (N = 448), ET (N = 128), or HC (N = 136) completed a multi-domain neuropsychological assessment consisting of memory, executive function, and attention/working memory domains. Participants also completed self-reported mood measures. Between-group differences in mood and cognition were assessed, and hierarchical regression models were conducted to examine relationships between mood and cognition in each group.Results Relative to the HC group, the PD and ET groups reported more mood symptoms and scored lower across all cognitive measures. There were no differences between the two movement disorder groups. Mood variables explained 3.9–13.7% of the total variance in cognitive domains, varying by disease group. For PD, apathy was the only unique predictor of executive function (β = −.114, p = .05), and trait anxiety was the only unique predictor of attention/working memory (β = −.188, p < .05). For ET, there were no unique predictors, though the overall models significantly predicted performance in the executive function and attention/working memory domains.Conclusions In a large cohort of ET and PD, we observed that the two groups had similar self-reported mood symptoms. Mood symptoms were differentially associated with cognition in PD versus ET. In PD, increased apathy was associated with worse executive function and higher trait anxiety predicted worse attention/working memory. For ET, there were no unique predictors, though the overall mood symptom severity was related to cognition. Our study highlights the importance of considering the relationship between mood and neuropsychological performance in individuals with movement disorders.
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mobile Decision Support System for Nurse Management of Neuromodulation Therapy, Cognitive Correlates of Mitochondrial Function in Older Adults, White Matter Connectivity and PD Cognitive Phenotypes, Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related Dementias, PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawing, University of Florida R25 Early Research Program for Neurology and Neurosurgery Residents, The Human Thalamocortical Network in Tourette Syndrome, Interdisciplinary Training in Movement Disorders and Neurorestoration, Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation, Web-based Automated Imaging Differentiation of Parkinsonism
OpenAlex ID: W4313546383