Work

Lipoxin A4 alleviates inflammation in Aspergillus fumigatus-stimulated human corneal epithelial cells by Nrf2/HO-1 signaling pathway.

Year: 2022

Type: article

Abstract: Purpose: -stimulated human corneal epithelial cells (HCECs). Methods: -stimulated HCECs. The nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation and expression in HCECs were detected by immunofluorescence staining. Results: -stimulated HCECs compared with the PBS control group. Pretreatment with brusatol (BT, Nrf2 inhibitor) or Zine Protoporphyrin (Znpp, HO-1 inhibitor) receded the anti-inflammatory ability of LXA4. Conclusions: -stimulated HCECs by inhibiting the expression of pro-inflammatory mediators through the Nrf2/HO-1 signaling pathway.

Source: PubMed Central

Authors: Xudong Peng, Xiaojia Zhu, Junjie Luan, Jing Lin, Yingxue Zhang, Qian Wang, Guiqiu Zhao

Institutions: Affiliated Hospital of Qingdao University, Tianjin Hospital, Wayne State University

Language: English

Topic: Ocular Surface and Contact Lens

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4313546545

FWCI: 0.421

Cites: 56

Cited by: 2

Related to: 10