Benefits of an Immunogenic Personalized Neoantigen Nanovaccine in Patients with High‐Risk Gastric/Gastroesophageal Junction Cancer (Adv. Sci. 1/2023)
Year: 2023
Type: article
Abstract: Nanovaccine In article number 2203298, Baorui Liu, Jia Wei, and co-workers prepare a personalized neoantigen nanovaccine (PNVAC) which spatially displays impressively enhanced lymph nodes trafficking capacity, and functionally induces more mature dendritic cells (DCs), neoantigen-specific T cells, and memory effector T cells. The PNVAC demonstrates superior protective efficacy against advanced gastric cancer recurrence and longer survival in preclinical studies and a phase I clinical trial.
Source: Advanced Science
Authors: Qin Liu, Yanhong Chu, Jie Shao, Hanqing Qian, Ju Yang, Huizi Sha, Lanqi Cen, Manman Tian, Qiuping Xu, Fangjun Chen, Yang Yang, Weifeng Wang, Kai Wang, Lixia Yu, Jia Wei, Baorui Liu
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,720
OpenAlex ID: W4313596349