Work

Author response: Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases

Year: 2022

Type: peer-review

Abstract: Computational methods based on both sequence and structure show evidence that tyrosine kinases are energetically biased to populate the 'DFG-out' type-II inhibitor binding conformation relative to serine/threonine kinases.

DOI: 10.7554/elife.83368.sa2

Authors: Joan Gizzio, Abhishek Thakur, Allan Haldane, Ronald M Levy

Institution: Temple University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Funders: Temple University, National Institutes of Health

Awards: Computer Cluster for Computational Biology and Biophysics, G9000133705, G9000144268

OpenAlex ID: W4313651000

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