A Macro-TSH: A Clinical Diagnostic Dilemma.
Year: 2022
Type: article
Study design: Case Report
Abstract: Isolated increase in thyrotropin stimulating hormone (TSH) in a clinically euthyroid patient may be caused by the formation of a macromolecule between TSH and autoantibodies causing discordant thyroid function test results. Despite the effort to eliminate interferences in immunoassays, these assays are still vulnerable to different interferences. Immunoassay interferences may cause erroneous results and lead to misdiagnosis which may subject a patient to unnecessary investigations and treatment. Immunoassays are affected by multiple substances; these may be endogenous or exogenous such as heterophile antibodies, autoantibodies, macromolecules, and human anti-mouse antibodies. This case reports a 47-year-old African woman who presented with a persistent elevated TSH with thyroid hormones within normal reference limits. She was found to have a macro-TSH which was associated with IgA paraprotein.
Source: PubMed Central
Authors: Xikombiso Nkuna, Zodwa Dire, Siyabonga Khoza
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4313655473