Work

Regulation of Helicobacter pylori Urease and Acetone Carboxylase Genes by Nitric Oxide and the CrdRS Two-Component System

Year: 2023

Type: article

Abstract: The molecular strategies used by Helicobacter pylori to colonize and persist in the harsh environment of the human stomach are a critical area of study. Our study identified several genes in this gastric pathogen, including ureA , a gene encoding a protein essential to the survival of H. pylori , that are regulated via the CrdRS two-component system (TCS) in response to nitric oxide (NO).

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.04633-22

Authors: Madison G. McKinsey, Miranda Y. Bate, Lauren M. Tramonte, Emely Y. Avalos, John Loh, Timothy L. Cover, Mark H. Forsyth

Institutions: William & Mary, Vanderbilt University, Vanderbilt University Medical Center, VA Tennessee Valley Healthcare System

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Structure and function of Helicobacter pylori VacA, G1726019755, Regulatory Mechanisms of Outer Membrane Protein Expression in Helicobacter pylori, G2507688059, G4461524289, G6337050363, G8136214783, Type IV Protein Secretion in Helicobacter pylori, H. pylori-induced Inflammation and Gastric Cancer

OpenAlex ID: W4313950084

FWCI: 3.027

Cites: 41

Cited by: 12

Related to: 10