Disease- and sex-specific differences in patients with heart valve disease: a proteome study
Year: 2023
Type: article
Study design: Observational Study
Abstract: Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients with aortic stenosis showed more proteins related to fibrosis and less to energy metabolism, whereas female patients showed strong reduction in proteostasis-related proteins. Clinical imaging was in line with proteomic findings, showing elevation of fibrosis in both patient groups and sex differences. Disease- and sex-specific proteomic profiles provide insight into cardiac remodeling in patients with heart valve disease and might help improve the understanding of molecular mechanisms and the development of individualized treatment strategies.
Source: Life Science Alliance
Authors: Sarah Nordmeyer, Milena Kraus, Matthias Ziehm, Marieluise Kirchner, Marie Schafstedde, Marcus Kelm, Sylvia Niquet, Mariet Mathew Stephen, Istvan Baczko, Christoph Knosalla, Matthieu-P Schapranow, Gunnar Dittmar, Michael Gotthardt, Martin Falcke, Vera Regitz-Zagrosek, Titus Kuehne, Philipp Mertins
Institutions: Deutsches Herzzentrum der Charité, German Centre for Cardiovascular Research, Hasso Plattner Institute, University of Potsdam, Max Delbrück Center, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, University of Szeged, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité – Universitätsmedizin Berlin, Luxembourg Institute of Health, University of Zurich, University Hospital Zurich
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
Funders: European Commission, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, Bundesministerium für Bildung und Forschung, Charité – Universitätsmedizin Berlin, Emberi Eroforrások Minisztériuma, Berlin Institute of Health, European Research Area Network on Cardiovascular Diseases, Horizon 2020 Framework Programme
Awards: G137732709, HiGHmed - Medizininformatik-Konsortium - Beitrag Hasso-Plattner-Institut, G2017605187, e:Med - Modul II - Verbundprojekt: SMART - Systemmedizin bei Herzinsuffizienz - Teilprojekt B, G2916289761, e:Med - Modul II - Verbundprojekt: SMART - Systemmedizin bei Herzinsuffizienz - Teilprojekt A, G360976936, G4937468798, Personalised Decision Support for Heart Valve Disease, G5712396478, Multiscale Modeling of Valvular Heart Diseases - Understanding the Mechanisms of Adverse Remodeling to Improve Precision Medicine, G7961716413, e:Med - Modul II - Verbundprojekt: SMART - Systemmedizin bei Herzinsuffizienz - Teilprojekt C, G934941519
OpenAlex ID: W4315478617