Sumoylation participates in the regulation of YB-1-mediated mismatch repair deficiency and alkylator tolerance.
Year: 2022
Type: article
Abstract: 1-type alkylator MNNG-induced cytotoxicity, G2/M-phase arrest, apoptosis, and the MMR-dependent DNA damage response. Collectively, these results provide molecular explanations for the impact of YB-1 sumoylation on MMR deficiency and alkylator tolerance, which may provide insight for designing therapeutic strategies for malignancies and alkylator-resistant cancers associated with YB-1 overexpression.
Source: PubMed
Authors: Ru-Tsun Mai, Chi-Hong Chao, Yao-Wen Chang, Yu-Ching Kao, Yi Cheng, Hsiang-Yu Hsu, Yi-Yuan Su, Chen-Yun Wang, Bo-Ying Lai
Institution: National Yang Ming Chiao Tung University
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4315619417