Retroviral Infection and Commensal Bacteria Dependently Alter the Metabolomic Profile in a Sterile Organ
Year: 2023
Type: article
Abstract: Both viruses and bacteria produce ‘pathogen associated molecular patterns’ that may affect microbial pathogenesis and anti-microbial responses. Additionally, bacteria produce metabolites while viruses could change metabolic profiles of the infected cells. Here, we used an unbiased metabolomics approach to profile metabolites in spleens and blood of Murine Leukemia Virus-infected mice monocolonized with Lactobacillus murinus to show that viral infection significantly changes the metabolite profile of monocolonized mice. We hypothesize that these changes could contribute to viral pathogenesis or to the host response against the virus and thus, open a new avenue for future investigations.
Source: Viruses
DOI: 10.3390/v15020386
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,892
Awards: G123948859, Molecular and Cellular Biology Training, G3311526080, G406168540, G5138532701, G5343362590, G7205445978, G7294357767, G7295898749, G7563597103, G7885114995, G9000012814, Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID), Cancer Center Support Grant, Virally-induced tumorigenesis controlled by the microbiota
OpenAlex ID: W4318478670