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Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Year: 2023

Type: article

Study design: Observational Study

Abstract: The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

Source: Diabetes Research and Clinical Practice

DOI: 10.1016/j.diabres.2023.110256

Authors: Antti-Mathias Taka, Anna But, Johanna Lempainen, Tommi Vatanen, Taina Härkönen, Jorma Ilonen, Mikael Knip

Institutions: University of Helsinki, Helsinki University Hospital, Helsinki Children's Hospital, University of Turku, Turku University Hospital, Broad Institute, Harvard University, University of Auckland, Tampere University Hospital

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,970

Funders: Medicinska Understödsföreningen Liv och Hälsa, Finska Läkaresällskapet, Lastentautien Tutkimussäätiö

OpenAlex ID: W4315644594

FWCI: 0.332

Cites: 8

Cited by: 2

Related to: 10