Work

Osteopontin and Cancer: Insights into Its Role in Drug Resistance

Year: 2023

Type: article

Abstract: Cancer is one of the leading causes of mortality worldwide. Currently, drug resistance is the main obstacle in cancer treatments with the underlying mechanisms of drug resistance yet to be fully understood. Osteopontin (OPN) is a member of the integrin binding glycophosphoprotein family that is overexpressed in several tumour types. It is involved in drug transport, apoptosis, stemness, energy metabolism, and autophagy, which may contribute to drug resistance. Thus, understanding the role of OPN in cancer drug resistance could be important. This review describes the OPN-based mechanisms that might contribute to cancer drug resistance, demonstrating that OPN may be a viable target for cancer therapy to reduce drug resistance in sensitive tumours.

Source: Biomedicines

DOI: 10.3390/biomedicines11010197

Authors: Chengcheng Hao, Jane Lane, Wen G. Jiang

Institutions: Capital Medical University, Beijing Shijitan Hospital, Cardiff University

Language: English

Topic: Bone and Dental Protein Studies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,447