Plasma concentrations of Per- and Polyfluoroalkyl Substances and alanine aminotransferase among Adolescents with and without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study
Year: 2022
Type: conference-abstract
Abstract: Background and aim. Ubiquitous exposure to per- and poly-fluoroalkyl substances (PFAS) may increase the risk of metabolic- and liver- related disorders, especially in children. In a cohort of adolescents with severe obesity, we investigated the association of plasma concentrations of PFAS and alanine aminotransferase (ALT), a predominantly hepatocellular, cytoplasmic enzyme that is a validated biomarker of liver damage. Methods Adolescents undergoing bariatric surgery were enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS, 2007-2012) study. Plasma measurements of six PFAS (PFHxS, PFHpS, PFOS, PFOA, PFNA, PFDA) were determined using liquid chromatography-mass spectrometry. For each PFAS, we generated linear models of PFAS and ALT controlling for covariates. We additionally evaluated the association of PFAS and ALT among those with histologically validated nonalcoholic fatty liver disease (NAFLD, including nonalcoholic fatty liver [NAFL] or nonalcoholic steatohepatitis [NASH]) and those without NAFLD. Results Of those enrolled, 129 individuals had available measures of plasma-PFAS and ALT measured preoperatively. NAFL (n=47) or NASH (n=27) was present in 74 (57.4%) of the 129 participants with severe obesity. Among all participants, positive associations were observed between plasma concentrations of PFOA and ALT (ß=4.0, 95% CI: 0.87, 7.1) measured prior to bariatric surgery. Among those with NAFLD, a significant association between PFOA and ALT was observed (ß=5.2, 95% CI:0.3, 10.2), which was not observed among those without NAFLD (ß=0.48, 95% CI: -2.6, 3.5). No associations were observed between ALT and other PFAS. Conclusions Higher plasma PFOA concentrations were found to be associated with higher concentrations of ALT in a cohort of adolescents with severe obesity, and among the subset with NAFLD in particular PFAS may be an important toxicant contributing to NAFLD progression. Key words: PFAS; NAFLD, obesity, environmental exposures, pediatric epidemiology
Source: ISEE Conference Abstracts
Authors: Brittney Baumert, Nikos Stratakis, Jesse Goodrich, Douglas I. Walker, Sandrah P. Eckel, Xiangping Lin, Scott Bartell, Yinqi Zhao, Damaskini Valvi, Thomas Inge, Todd Jenkins, Justin Ryder, Rohit Kohli, Stephanie Sisley, Stavra Xanthakos, Zoe Coates Fuentes, Sarah Rock, Max Aung, Michele Andrea La Merrill, Rob McConnnell, David V. Conti, Leda Chatzi
Institutions: University of Southern California, Barcelona Institute for Global Health, Icahn School of Medicine at Mount Sinai, University of California, Irvine, Northwestern University, Lurie Children's Hospital, Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Minnesota, Children's Hospital of Los Angeles, Baylor College of Medicine, University of California, Davis
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4316924495