Effects of Ambient Air Pollutants on Cardiac Structure and Function in ECHO-SOL
Year: 2022
Type: conference-abstract
Abstract: Background and Aim The relationship between air pollution (AP) exposure and incident heart failure has been investiagted; less is known about effects of AP on subclinical cardiac structure and function preceding clinical diagnosis. Cross-sectional associations between fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and echocardiographic were assessed among 1,660 participants aged 45-74 years of the Echocardiographic Study of Latinos, an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods Measures including left ventricular (LV) mass index, relative wall thickness, average global longitudinal strain (GLS), LV ejection fraction, e’, left atrial volume index, E/e’ ratio, and diastolic function grades were assessed by echocardiogram. AP concentrations were estimated from spatio-temporal models at participant building residence. Primary exposures were interquartile range (IQR) increases in annual average PM2.5 and NO2 prior to clinical visit 1 (2008-2011). Survey linear regression estimated the effect of AP on measures of cardiac structure and function adjusting for age, sex, study site, alcohol use, physical activity, and education. Strain measurements are expressed as negative percentages (more positive numbers indicating worse myocardial strain). Results 42.3% were male and 35.4% had no high school diploma. Average concentrations for PM2.5 and NO2 were 10.30 µg/m3 (standard deviation (SD) 1.9) and 17.4 ppb (SD 6.3), respectively. PM2.5 was associated with increased (worse) GLS (2.40%; 95% CI 1.03, 3.76) and decreased LV ejection fraction (-2.36; 95% CI -4.34, -0.38) per IQR increase. NO2 was associated with increased GLS (1.57; 95% CI 0.69, 2.46) and decreased LV ejection fraction (-2.07; 95% CI -3.77, -0.37) per IQR increase. Associations with other measures of cardiac structure and function were not found. Conclusion These results provide evidence that in this Hispanic/Latino cohort, AP adversely affects GLS and EF, both known precursors to clinical heart failure.
Source: ISEE Conference Abstracts
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4316924832